LAB Publications
Curtis Clock Lab members in bold
*Equal Contributors
2024
Butler CT, Rodgers AM, Curtis AM, Donnelly RF.
Chrono-tailored drug delivery systems: recent advances and future directions.
Drug Deliv Transl Res. 2024 Feb 28. doi: 10.1007/s13346-024-01539-4. Online ahead of print.PMID: 38416386
Rehill AM, Leon G, McCluskey S, Schoen I, Hernandez-Santana Y, Annett S, Klavina P, Robson T, Curtis AM, Renné T, Hussey S, O'Donnell JS, Walsh PT, Preston RJS.
Glycolytic reprogramming fuels myeloid cell-driven hypercoagulability.
J Thromb Haemost. 2024 Feb;22(2):394-409. doi: 10.1016/j.jtha.2023.10.006. Epub 2023 Oct 20.PMID: 37865288
2023
Cox SL, O'Siorain JR, He Y, Lordan R, Naik A, Tang SY, Sengupta S, FitzGerald GA, Carroll RG, Curtis AM.
Circadian disruption in lung fibroblasts enhances NF-κB activity to exacerbate neutrophil recruitment.
FASEB J. 2023 Feb;37(2):e22753. doi: 10.1096/fj.202201456R.
2022
Curtis AM, Carroll RG.
Aging alters rhythms in immunity.
Nat Immunol. 2022 Feb;23(2):153-154. doi: 10.1038/s41590-021-01099-6.
O'Siorain JR, Curtis AM.
Circadian Control of Redox Reactions in the Macrophage Inflammatory Response.
Antioxid Redox Signal. 2022 Mar 29. doi: 10.1089/ars.2022.0014.
Cox SL, O'Siorain JR, Fagan LE, Curtis AM, Carroll RG
Intertwining roles of circadian and metabolic regulation of the innate immune response.
Semin Immunopathol. 2022 Mar;44(2):225-237. doi: 10.1007/s00281-021-00905-5. Epub 2022 Jan 12.
Drakeford C, Aguila S, Roche F, Hokamp K, Fazavana J, Cervantes MP, Curtis AM, Hawerkamp HC, Dhami SPS, Charles-Messance H, Hackett EE, Chion A, Ward S, Ahmad A, Schoen I, Breen E, Keane J, Murphy R, Preston RJS, O'Sullivan JM, Sheedy FJ, Fallon P, O'Donnell JS.
von Willebrand factor links primary hemostasis to innate immunity.
Nat Commun. 2022 Nov 3;13(1):6320. doi: 10.1038/s41467-022-33796-7.
Cervantes-Silva MP, Carroll RG, Wilk MM, Moreira D, Payet CA, O'Siorain JR, Cox SL, Fagan LE, Klavina PA, He Y, Drewinski T, McGinley A, Buel SM, Timmons GA, Early JO, Preston RJS, Hurley JM, Finlay DK, Schoen I, Javier Sánchez-García F, Mills KHG, Curtis AM.
The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing.
Nat Commun. 2022 Dec 5;13(1):7217. doi: 10.1038/s41467-022-34897-z.
Klavina PA, Leon G, Curtis AM, Preston RJS.
Dysregulated haemostasis in thrombo-inflammatory disease.
Clin Sci (Lond). 2022 Dec 22;136(24):1809-1829. doi: 10.1042/CS20220208.
2021
Collins EJ, Cervantes-Silva MP, Timmons GA, O'Siorain JR, Curtis AM, Hurley JM
Post-transcriptional circadian regulation in macrophages organizes temporally distinct immunometabolic states.
Genome Res. 2021 Jan 12;31(2):171-85. doi: 10.1101/gr.263814.120.
Sengupta S, Ince L, Sartor F, Borrmann H, Zhuang X, Naik A,* Curtis A, *McKeating JA
Clocks, Viruses, and Immunity: Lessons for the COVID-19 Pandemic.
J Biol Rhythms. 2021 Feb;36(1):23-34. doi: 10.1177/0748730420987669. Epub 2021 Jan 22.
Dowling JK, Afzal R, Gearing LJ, Cervantes-Silva MP, Annett S, Davis GM, De Santi C, Assmann N, Dettmer K, Gough DJ, Bantug GR, Hamid FI, Nally FK, Duffy CP, Gorman AL, Liddicoat AM, Lavelle EC, Hess C, Oefner PJ, Finlay DK, Davey GP, Robson T, Curtis AM, Hertzog PJ, Williams BRG, McCoy CE
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages.
Nat Commun. 2021 Mar 5;12(1):1460. doi: 10.1038/s41467-021-21617-2.
Cervantes-Silva MP, Cox SL, Curtis AM
Alterations in mitochondrial morphology as a key driver of immunity and host defence.
EMBO Rep. 2021 Sep 6;22(9):e53086. doi: 10.15252/embr.202153086. Epub 2021 Aug 2.PMID: 34337844
Early JO, Fagan LE, Curtis AM, Kennedy OD
Mitochondria in Injury, Inflammation and Disease of Articular Skeletal Joints.
Front Immunol. 2021 Sep 3;12:695257. doi: 10.3389/fimmu.2021.695257. eCollection 2021
Timmons GA, Carroll RG, O'Siorain JR, Cervantes-Silva MP, Fagan LE, Cox SL, Palsson-McDermott E, Finlay DK, Vincent EE, Jones N, Curtis AM.
The Circadian Clock Protein BMAL1 Acts as a Metabolic Sensor In Macrophages to Control the Production of Pro IL-1β.
Front Immunol. 2021 Nov 9;12:700431. doi: 10.3389/fimmu.2021.700431. eCollection 2021.PMID: 34858390
2020
Jacob H, * Curtis AM, * Kearney CJ.
Therapeutics on the clock: Circadian medicine in the treatment of chronic inflammatory diseases.
Biochem Pharmacol. 2020 Sep 30:114254. doi: 10.1016/j.bcp.2020.114254. Online ahead of print.PMID: 33010213 Review.
Timmons GA, O'Siorain JR, Kennedy OD, * Curtis AM, * Early JO.
Innate Rhythms: Clocks at the Center of Monocyte and Macrophage Function.
Front Immunol. 2020 Aug 4;11:1743. doi: 10.3389/fimmu.2020.01743. Review.
2019
Hudson N, Celkova L, Hopkins A, Greene C, Storti F, Ozaki E, Fahey E, Theodoropoulou S, Kenna PF, Humphries MM,
Curtis AM, Demmons E, Browne A, Liddie S, Lawrence MS, Grimm C, Cahill MT, Humphries P, Doyle SL, Campbell M.
Dysregulated claudin-5 cycling in the inner retina causes retinal pigment epithelial cell atrophy.
JCI Insight. 2019 Aug 8;4(15). pii: 130273. doi: 10.1172/jci.insight.130273. eCollection 2019 Aug 8.
Carroll RG, Timmons GA, Cervantes-Silva MP, Kennedy OD, Curtis AM.
Immunometabolism around the Clock
Trends Mol Med. 2019 May 29. pii: S1471-4914(19)30102-9. doi: 10.1016/j.molmed.2019.04.013. [Epub ahead of print]
Review.
Geiger SS, Curtis AM, O'Neill LAJ, Siegel RM.
Daily Variation in Macrophage Phagocytosis is Clock-independent and Dispensable for Cytokine Production.
Immunology. 2019 Feb 18. doi: 10.1111/imm.13053. [Epub ahead of print]
2018
Selvarajah L, Curtis AM, Kennedy OD.
Bone Microdamage in Acute Knee Injury.
Curr Rheumatol Rep. 2018 Nov 21;20(12):89. doi: 10.1007/s11926-018-0791-8. Review.
Early JO, Menon D, Wyse CA, Cervantes-Silva MP, Zaslona Z, Carroll RG, Palsson-McDermott EM, Angiari S, Ryan DG, Corcoran SE, Timmons G, Geiger SS, Fitzpatrick DJ, O'Connell D, Xavier RJ, Hokamp K, O'Neill LAJ, Curtis AM.
Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2.
Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8460-E8468. doi: 10.1073/pnas.1800431115. Epub 2018 Aug 20.
Wyse CA, Zhang X, McLaughlin M, Biello SM, Hough D, Bellingham M, Curtis AM, Robinson JE, Evans NP.
Circadian rhythms of melatonin and behaviour in juvenile sheep in field conditions: Effects of photoperiod, environment and weaning.
Physiol Behav. 2018 Jun 9. pii: S0031-9384(18)30296-8. doi: 10.1016/j.physbeh.2018.06.001
Wyse CA, Celis Morales CA, Ward J, Lyall D, Smith DJ, Mackay D, Curtis AM, Bailey MES, Biello S, Gill JMR, Pell JP. Population-level seasonality in cardiovascular mortality, blood pressure, BMI and inflammatory cells in UK biobank. Ann Med. 2018 May 18:1-10. doi: 10.1080/07853890.2018.1472389
Romain A Colas, Patricia R Souza, Mary E Walker, Maudrian Burton, Zbigniew Zasłona, Annie M Curtis, Raquel M Marques, Jesmond Dalli
Impaired Production and Diurnal Regulation of Vascular RvDn-3 DPA Increases Systemic Inflammation and Cardiovascular Disease.
Circ Res. 2018 Feb 5. pii: CIRCRESAHA.117.312472. doi: 10.1161/CIRCRESAHA.117.312472. [Epub ahead of print]
Lyall LM, Wyse CA, Celis-Morales CA, Lyall DM, Cullen B, Mackay D, Ward J, Graham N, Strawbridge RJ, Gill JMR, Ferguson A, Bailey MES, Pell JP, Curtis AM, Smith DJ.
Seasonality of depressive symptoms in women but not in men: A cross-sectional study in the UK Biobank cohort.
J Affect Disord. 2018 Jan 4;229:296-305. doi: 10.1016/j.jad.2017.12.106. [Epub ahead of print] PMID: 29329063
2017
Sutton CE, Finlay CM, Raverdeau M, Early JO, DeCourcey J, Zaslona Z, O'Neill LAJ, * Mills KHG, * Curtis AM.
Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease.
Nat Commun. 2017 Dec 12;8(1):1923. doi: 10.1038/s41467-017-02111-0. PMID: 29234010
Zaslona Z1, Case S, Early JO, Lalor SJ, McLoughlin RM, *Curtis AM, * O'Neill LA .
The circadian protein BMAL1 in myeloid cells is a negative regulator of allergic asthma
Am J Physiol Lung Cell Mol Physiol. 2017 Mar 23:ajplung.00072.2017. doi: 10.1152/ajplung.00072.2017. PMID: 28336811 (Mar 2017)
Wyse CA, Celis Morales CA, Graham N, Fan Y, Ward J, Curtis AM, Mackay D, Smith DJ, Bailey ME, Biello S, Gill JM, Pell JP. .
Adverse metabolic and mental health outcomes associated with shiftwork in a population-based study of 277,168 workers in UK biobank.
Ann Med. 2017 Feb 6:1-23. doi: 10.1080/07853890.2017.1292045. PMID: 28166415 (Feb 2017)
2016
McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP .
Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion.
Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7778-E7787 PMID: 27856732 (Nov 2016)
Early JO, Curtis AM. .
Immunometabolism: Is it under the eye of the clock?
Semin Immunol. 2016 Oct;28(5):478-490. doi: 10.1016/j.smim.2016.10.006. Review. PMID: 27884543 (Oct 2016)
Curtis AM, Fagundes CT. .
Understanding the Role of Cellular Molecular Clocks in Controlling the Innate Immune Response
Methods Mol Biol. 2016;1390:301-16. doi: 10.1007/978-1-4939-3335-8_19 PMID: 26803637 (Jan 2016)
2015
* Curtis AM, * Fagundes CT, Yang G, Palsson-McDermott EM, Wochal P, McGettrick AF, Foley NH, Early JO, Chen L, Zhang H, Xue C, Geiger SS, Hokamp K, Reilly MP, Coogan AN, Vigorito E, FitzGerald GA, O'Neill LA .
Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1.
Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7231-6. PMID: 25995365 (Jun 2015)
Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnston DG, Jiang JK, Israelsen WJ, Keane J, Thomas C, Clish C, Vander Heiden M, Xavier RJ, O'Neill LA. .
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.
Cell Metab. 2015 Jan 6;21(1):65-80 PMID: 25565206 (Jan 2015)
2014
Curtis AM, Bellet MM, Sassone-Corsi P, O'Neill LA. .
Circadian clock proteins and immunity.
Immunity. 2014 Feb 20;40(2):178-86 PMID: 24560196 (Feb 2014)
2013
Yang G, Paschos G, Curtis AM, Musiek ES, McLoughlin SC, FitzGerald GA .
Knitting up the raveled sleave of care.
Sci Transl Med. 2013 Nov 20;5(212):212rv3 PMID: 24259052 (Nov 2013)
Curtis AM, Edelberg J, Jonas R, Rogers WT, Moore JS, Syed W, Mohler ER 3rd .
Endothelial microparticles: sophisticated vesicles modulating vascular function.
Vasc Med. 2013 Aug;18(4):204-14 PMID: 23892447 (Aug 2013)
Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LA. .
Succinate is an inflammatory signal that induces IL-1β through HIF-1α.
Nature. 2013 Apr 11;496(7444):238-42 PMID: 23535595 (Apr 2013)
Curtis AM, FitzGerald GA .
Platelet microRNAs: Novy Mir* or mired in human complexity?
Circ Res. 2013 Feb 15;112(4):576-8. PMID: 23410874 (Feb 2013)
GAP IN PUBLICATIONS DUE TO NON-RESEARCH POSITIONS 2008-2011
2010
Curtis AM, Zhang L, Medenilla E, Gui M, Wilkinson PF, Hu E, Giri J, Doraiswamy V, Gunda S, Burgert ME, Moore JS, Edelberg JM, Mohler ER 3rd .
Relationship of microparticles to progenitor cells as a measure of vascular health in a diabetic population.
Cytometry B Clin Cytom. 2010 Sep;78(5):329-37 PMID: 20544836 (Sep 2010)
2009
Curtis AM, Wilkinson PF, Gui M, Gales TL, Hu E, Edelberg JM .
p38 mitogen-activated protein kinase targets the production of proinflammatory endothelial microparticles.
J Thromb Haemost. 2009 Apr;7(4):701-9 PMID: 19192109 (Apr 2009)
2008
Price TS, Baggs JE, Curtis AM, Fitzgerald GA, Hogenesch JB. .
WAVECLOCK: wavelet analysis of circadian oscillation.
Bioinformatics. 2008 Dec 1;24(23):2794-5 PMID: 18931366 (Dec 2008)
Reilly DF, Curtis AM, Cheng Y, Westgate EJ, Rudic RD, Paschos G, Morris J, Ouyang M, Thomas SA, FitzGerald GA. .
Peripheral circadian clock rhythmicity is retained in the absence of adrenergic signaling.
Arterioscler Thromb Vasc Biol. 2008 Jan;28(1):121-6. PMID: 17975121 (Jan 2008)
2007
Curtis AM, Cheng Y, Kapoor S, Reilly D, Price TS, Fitzgerald GA .
Circadian variation of blood pressure and the vascular response to asynchronous stress.
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3450-5 PMID: 17360665 (Feb 2007)
2006
Woon PY, Curtis AM, Kaisaki PJ, Argoud K, Wallace KJ, Bihoreau MT, FitzGerald GA, Gauguier D .
Genomic organization of the rat Clock gene and sequence analysis in inbred rat strains.
Genomics. 2006 Feb;87(2):208-17 PMID: 16376516 (Feb 2006)
Curtis AM, Fitzgerald GA. .
Central and peripheral clocks in cardiovascular and metabolic function.
Ann Med. 2006;38(8):552-9 PMID: 17438670 (Jan 2006)
2005
Rudic RD, McNamara P, Reilly D, Grosser T, Curtis AM, Price TS, Panda S, Hogenesch JB, FitzGerald GA .
Bioinformatic analysis of circadian gene oscillation in mouse aorta.
Circulation. 2005 Oct 25;112(17):2716-24 PMID: 16230482 (Oct 2005)
Rudic RD, Curtis AM, Cheng Y, FitzGerald G. .
Peripheral clocks and the regulation of cardiovascular and metabolic function.
Methods Enzymol. 2005;393:524-39 PMID: 15817310 (Jan 2005)
2004
Rudic RD, McNamara P, Curtis AM, Boston RC, Panda S, Hogenesch JB, Fitzgerald GA. .
BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis.
PLoS Biol. 2004 Nov;2(11):e377 PMID: 15523558 (Nov 2004)
Curtis AM, Seo SB, Westgate EJ, Rudic RD, Smyth EM, Chakravarti D, FitzGerald GA, McNamara P. .
Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.
J Biol Chem. 2004 Feb 20;279(8):7091-7 PMID: 14645221 (Feb 2004)
2003
Bairead E, Harmon DL, Curtis AM, Kelly Y, O'Leary C, Gardner M, Leahy DT, Vaughan P, Keegan D, O'Morain C, O'Donoghue D, Shanahan F, Parfrey NA, Quane KA. .
Association of NOD2 with Crohn's disease in a homogenous Irish population.
Eur J Hum Genet. 2003 Mar;11(3):237-44 PMID: 12673278 (Mar 2003)
2002
Zhang Z, Sapiro R, Kapfhamer D, Bucan M, Bray J, Chennathukuzhi V, McNamara P, Curtis A, Zhang M, Blanchette-Mackie EJ, Strauss JF 3rd.
A sperm-associated WD repeat protein orthologous to ChlamydomonasPF20 associates with Spag6, the mammalian orthologue of Chlamydomonas PF16.
Mol Cell Biol. 2002 Nov;22(22):7993-8004. doi: 10.1128/MCB.22.22.7993-8004.2002.PMID: 12391165