We were very happy to get Georges paper published in Frontiers in Immunology, given the difficulties of trying to conduct research during Covid. It was a real team effort and everyone from the lab got stuck in and helped out. We demonstrated that when macrophages ( important cells of our immune system) lack one of the key body clock genes, Bmal1, these immune cells feed themselves very differently and consume much more glucose (sugar). This causes the cells to be hyper-inflammatory. Our study sheds further light as to why disruption of our body clocks tends to lead to chronic inflammatory disease.
You can find the research paper here
Coverage by BBC Science focus here
Here is an old picture of George and Mariana (pre-Covid) after they had gotten a good result for the paper.
Both have gone onto great things outside academic research, and we miss them both dearly.
